Inhibitory actions of ZENECA ZD7288 on whole-cell hyperpolarization activated inward current (If) in guinea-pig dissociated sinoatrial node cells
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چکیده
منابع مشابه
Hyperpolarization-Activated Current, If, in Mathematical Models of Rabbit Sinoatrial Node Pacemaker Cells
A typical feature of sinoatrial (SA) node pacemaker cells is the presence of an ionic current that activates upon hyperpolarization. The role of this hyperpolarization-activated current, If, which is also known as the "funny current" or "pacemaker current," in the spontaneous pacemaker activity of SA nodal cells remains a matter of intense debate. Whereas some conclude that If plays a fundament...
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The temperature dependence of hyperpolarization-activated current (I(h)) was investigated in freshly isolated guinea pig ileal smooth muscle cells, using the nystatin-perforated whole cell recording technique. Hyperpolarizing pulses (-50 to -120 mV) from -40 mV evoked time-dependent inward rectifying currents with a reversal potential of -33 mV and a slow activation time course well approximate...
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The slow inward current (is) in the rabbit sinoatrial node cell was studied by the conventional two-microelectrode voltage clamp technique. When is was measured as the difference between two records obtained before and after blocking is with D 600, the fully activated current (is)-voltage relation was non-linear; the conductance decreased in the negative potential range resulting in an almost c...
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Several time- and voltage-dependent ionic currents have been identified in cardiac pacemaker cells, including Na(+) current, L- and T-type Ca(2+) currents, hyperpolarization-activated cation current, and various types of delayed rectifier K(+) currents. Mathematical models have demonstrated that spontaneous action potentials can be reconstructed by incorporating these currents, but relative con...
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Yukiko Himeno, Futoshi Toyoda, Hiroyasu Satoh, Akira Amano, Chae Young Cha, Hiroshi Matsuura, and Akinori Noma Department of Diabetes and Clinical Nutrition, Faculty of Medicine, Kyoto University, Kyoto; Department of Physiology, Faculty of Medicine, Shiga University of Medical Science, Shiga; Department of Pharmacology, Faculty of Medicine, Nara Medical University, Nara; and Department of Bios...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1993
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1993.tb13815.x